T4 Euthymed 50 mcg – Levothyroxine Sodium Tablets

Active ingredient: Levothyroxine Sodium (T4)
Type: Thyroid
Form: Oral (pills)

Levothyroxine is a synthetic form of thyroxine (T4), the natural thyroid hormone produced by the thyroid gland. T4 is converted in the body into T3 (the biologically active thyroid hormone). Both hormones bind to thyroid receptors in the cell nucleus, influencing DNA transcription, protein synthesis, metabolism, energy production, and cellular function. Levothyroxine is identical to naturally occurring L-thyroxine.

Purposes of Use

Levothyroxine is prescribed for:

• Hypothyroidism (underactive thyroid)

• Conditions where thyroid hormone production is reduced

• Thyroid removal or damage from radiation, medications, or surgery

It replaces or supplements natural thyroid hormones to restore normal metabolic function. Low thyroid hormone can cause weight gain, fatigue, depression, slow metabolism, poor performance, and reduced recovery.

Enhanced Metabolism

By restoring thyroid function, Levothyroxine helps optimize metabolic rate. This supports fat loss phases, muscle definition, and efficient nutrient utilization.

Increased Energy Levels
Improved thyroid activity boosts stamina, energy, and endurance — crucial for intense training.

Improved Muscle Recovery
Balanced thyroid hormones enhance protein synthesis and tissue repair.

Weight Management
Thyroid stability supports healthy weight control and body composition.

Consistent Performance
Stable thyroid hormones improve physical and mental performance for athletes requiring high daily output.

Use with Growth Hormone

Patients using Human Growth Hormone (HGH) often require additional T4.
HGH accelerates conversion of T4 → T3, which can cause T4 deficiency.
Supplementing with T4 prevents thyroid suppression during HGH cycles.

Dosage and Administration

• Take Levothyroxine on an empty stomach

• 30–60 minutes before meals

• Swallow with a full glass of water

• Dosage varies based on age, body weight, thyroid condition, and medical guidance

Maximum dosing may reach 300–400 mcg/day, but this is rare. Most people must start low and titrate carefully under medical supervision.

How to Use

• Start with 25–50 mcg/day

• Increase by 25–50 mcg every 5–6 days

• Maximum: 300–400 mcg/day

• Divide doses throughout the day

• Cycle length: up to 7 weeks

• Minimum 6 weeks off between cycles to restore natural thyroid function

• Commonly stacked with clenbutos for enhanced fat-burning effects

Average dose: 100–200 mcg/day
Effective method: Pyramidal tapering
Typical cycle length: 5–6 weeks

Pharmacokinetics

• Oral absorption: 40–80%

• Absorption increases with fasting

• Decreased by certain medical conditions, foods, age

• Half-life:

  • 6–7 days (normal thyroid)

  • 9–10 days (hypothyroidism)

  • 3–4 days (hyperthyroidism)

• 80% eliminated via kidneys

• 20% eliminated through stool

Effects

• Regulates metabolism

• Enhances fat burning

• Increases anabolic processes and muscle growth

• Stimulates central nervous system

Side Effects

Allergic reactions are rare but require immediate medical attention if they occur.

Side effects are usually due to overdosing, including:

• Weight loss

• Heat intolerance

• Sweating

• Anxiety

• Insomnia

• Tremors

• Rapid heartbeat

• Not recommended after recent heart attack

Acute overdose may cause:

• Fever

• Hypoglycemia

• Heart failure

• Coma

• Adrenal insufficiency

• May require beta-blockers

Symptoms of overdose may appear 6 hours to 11 days later.

Additional symptoms:

• Chest discomfort

• Difficulty swallowing

• Extreme fatigue

• Irregular or fast heartbeat

• Nausea

• Tremors

• Excessive sweating

Profile

• Half-life: 6–24 hours

• Frequency: 1–2 times daily

Precautions

High-dose prolonged use can:

• Suppress natural thyroid hormone production

• Cause long-term endocrine imbalance

• Studies show up to 20% suppression after 3 weeks of high dosing

When used properly, thyroid function typically restores within 3–4 weeks.

Levothyroxine has adrenaline-like effects (rapid heartbeat, nervousness), which may be prevented with beta-blockers.

Contraindications

Do not use in:

• Hypersensitivity to Levothyroxine

• Acute myocardial infarction

• Any form of thyrotoxicosis

• Uncorrected adrenal insufficiency (may trigger adrenal crisis)

Drug Interactions

Avoid taking within close timing of:

• Calcium or iron supplements (4 hours apart)

• Soy products (3 hours apart)

• Aluminum/magnesium antacids

• Simethicone or sucralfate

• Cholestyramine, colestipol, Kayexalate

Other interactions:

• Ketamine → hypertension, tachycardia

• Tricyclic antidepressants → increased toxicity

• Lithium → affects iodine metabolism, reduces effectiveness

Special Warnings

Introduce very gradually in:

• Patients over 50

• Long-standing hypothyroidism

• Cardiovascular conditions

• Angina or coronary artery disease

• Hypertension

• Elderly patients with possible heart issues

Use caution with:

• Diabetes mellitus

• Diabetes insipidus

Subclinical hyperthyroidism may cause bone loss; dosage should be kept at the lowest effective level.

Storage

• Keep out of reach of children

• Store in a cool, dry place

• Avoid direct sunlight

• Keep at room temperature

• Do not use after expiry date