Ezetimibe 10 mg – Cholesterol Absorption Inhibitor for Cardiovascular Support

What is Ezetimibe?

Ezetimibe is a modern cholesterol-lowering medication used to reduce LDL, total cholesterol, and overall cardiovascular risk.

Unlike statins, which work in the liver, Ezetimibe acts in the intestines, blocking the absorption of both dietary and bile-derived cholesterol.

Because it uses a completely different mechanism of action, it pairs exceptionally well with statins, significantly boosting their cholesterol-lowering efficiency.

This makes Ezetimibe particularly valuable for athletes using PEDs or AAS, which often cause elevated LDL and decreased HDL — a major cardiovascular risk factor in enhanced athletes.

Main Effects of Ezetimibe

• ???? Reduces LDL cholesterol levels

• ???? Moderately lowers total cholesterol and triglycerides

• ????️ Enhances HDL preservation when combined with statins (e.g., Pitavastatin)

• ???? Less liver stress compared to high-dose statin monotherapy

• ???? Cardiovascular protection for athletes using AAS/PEDs

How to Take Ezetimibe

Dosage, Schedule & Combinations

For users of AAS, the same dosing is continued throughout the cycle and 4–6 weeks post-cycle to stabilize the lipid profile and protect cardiovascular health.

The dose is generally fixed at 10 mg/day — no buildup needed.

Monitoring recommended:

• LDL / HDL / total cholesterol

• Triglycerides

• Liver enzymes (ALT, AST) — especially with statins

Precautions

• Avoid combining with cyclosporine (may increase drug concentration)

• Monitor ALT/AST if taken with statins

• Use carefully in patients with liver impairment

Possible Side Effects

Usually mild and uncommon:

• Mild digestive issues (diarrhea, abdominal discomfort)

• Headache

• Fatigue

In combination with statins:

• Higher risk of muscle pain (though still lower than with strong statins alone)

How to Store

• Store in a dry place below 25°C

• Keep away from sunlight

• Keep out of reach of children

• Use before the expiration date

How Ezetimibe Works

Ezetimibe acts in the small intestine, where it blocks the NPC1L1 transporter, a protein responsible for transferring dietary and bile cholesterol into the bloodstream.

By shutting this “cholesterol gate,” the drug prevents cholesterol absorption and allows it to be naturally excreted.

As cholesterol availability decreases, the liver increases the number of LDL receptors, pulling more LDL out of the blood — significantly lowering LDL levels.

When combined with statins, which reduce internal cholesterol synthesis, the effect becomes strongly synergistic, providing the most effective non-invasive lipid control.

This combination is highly recommended for AAS users, where LDL increases and HDL decreases dramatically, raising cardiovascular risk.

FAQ

Can Ezetimibe be taken with statins like Pitavastatin, Atorvastatin, or Rosuvastatin?
Yes. It is commonly prescribed with statins for superior LDL reduction.

Does Ezetimibe affect training performance or muscle recovery?
No, it does not negatively affect muscle tissue or recovery processes.

Does Ezetimibe reduce absorption of nutrients?
At high doses, it may slightly reduce absorption of fat-soluble vitamins (A, D, E, K), but this effect is minimal at normal therapeutic doses.